Thymic Gene Transfer of Myelin Oligodendrocyte Glycoprotein Ameliorates the Onset but Not the Progression of Autoimmune Demyelination

Tolerance induction, and thus prevention of autoimmunity, is linked with the amount of self-antigen presented on thymic stroma. We describe that intrathymic (i.t.) delivery of the autoantigen, myelin oligodendrocyte glycoprotein (MOG), via a lentiviral vector (LV), led to tolerance induction and pre...

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Bibliografiske detaljer
Main Authors: Siatskas, Christopher, Seach, Natalie, Sun, Guizhi, Emerson-Webber, Ashley, Silvain, Aude, Toh, Ban-Hock, Alderuccio, Frank, Bäckström, B Thomas, Boyd, Richard L, Bernard, Claude C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392978/
https://ncbi.nlm.nih.gov/pubmed/22354375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.15
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