Effects of Ascorbic Acid on Carcinogenicity and Acute Toxicity of Nickel Subsulfide, and on Tumor Transplants Growth in Gulonolactone Oxidase Knock-Out Mice and Wild-type C57BL Mice

The aim of this study was to test a hypothesis that ascorbate depletion could enhance carcinogenicity and acute toxicity of nickel. Homozygous L-gulono-<gamma>-lactone oxidase gene knock-out mice (Gulo-/- mice) unable to produce ascorbate and wild-type C57BL mice (WT mice) were injected intram...

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Detalhes bibliográficos
Main Authors: Kasprzak, Kazimierz S., Diwan, Bhalchandra A., Kaczmarek, Monika Z., Logsdon, Daniel L., Fivash, Mathew J., Salnikow, Konstantin
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392721/
https://ncbi.nlm.nih.gov/pubmed/21878346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.08.015
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