Mitochondrial Gene Therapy Improves Respiration, Biogenesis, and Transcription in G11778A Leber's Hereditary Optic Neuropathy and T8993G Leigh's Syndrome Cells

Many incurable mitochondrial disorders result from mutant mitochondrial DNA (mtDNA) and impaired respiration. Leigh's syndrome (LS) is a fatal neurodegenerative disorder of infants, and Leber's hereditary optic neuropathy (LHON) causes blindness in young adults. Treatment of LHON and LS ce...

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Main Authors: Iyer, Shilpa, Bergquist, Kristen, Young, Kisha, Gnaiger, Erich, Rao, Raj R., Bennett, James P.
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2012
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392617/
https://ncbi.nlm.nih.gov/pubmed/22390282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.177
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