Structural characterization of H. pylori dethiobiotin synthetase reveals differences between family members

Dethiobiotin synthetase (DTBS) is involved in the biosynthesis of biotin in bacteria, fungi and plants. As humans lack this pathway, dethiobiotin synthetase is a promising antimicrobial drug target. We determined structures of DBTS from H. pylori (hpDTBS) bound with cofactors and a substrate analog...

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Detalhes bibliográficos
Main Authors: Porebski, Przemyslaw J., Klimecka, Maria, Chruszcz, Maksymilian, Nicholls, Robert A., Murzyn, Krzysztof, Cuff, Marianne E., Xu, Xiaohui, Cymborowski, Marcin, Murshudov, Garib N., Savchenko, Alexei, Edwards, Aled, Minor, Wladek
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392494/
https://ncbi.nlm.nih.gov/pubmed/22284390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2012.08506.x
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