Evidence for Astrocytes as a Potential Source of the Glutamate Excess in Temporal Lobe Epilepsy

Increased extracellular brain glutamate has been implicated in the pathophysiology of human refractory temporal lobe epilepsy (TLE), but the cause of the excessive glutamate is unknown. Prior studies by us and others have shown that the glutamate degrading enzyme glutamine synthetase (GS) is deficie...

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Detalhes bibliográficos
Main Authors: Perez, Edgar L, Lauritzen, Fredrik, Wang, Yue, Lee, Tih-Shih W, Kang, Dewey, Zaveri, Hitten P, Chaudhry, Farrukh A, Ottersen, Ole P, Bergersen, Linda H, Eid, Tore
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392431/
https://ncbi.nlm.nih.gov/pubmed/22659305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.05.010
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