Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment

Statins are widely prescribed for reducing LDL-cholesterol (C) and risk for cardiovascular disease (CVD), but there is considerable variation in therapeutic response. We used a gas chromatography-time-of-flight mass-spectrometry-based metabolomics platform to evaluate global effects of simvastatin o...

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Detalhes bibliográficos
Main Authors: Trupp, Miles, Zhu, Hongjie, Wikoff, William R., Baillie, Rebecca A., Zeng, Zhao-Bang, Karp, Peter D., Fiehn, Oliver, Krauss, Ronald M., Kaddurah-Daouk, Rima
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392268/
https://ncbi.nlm.nih.gov/pubmed/22808006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038386
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