A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co-segregates with schizophrenia, bipolar disorder and depression. We previously reported that the translocation red...

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Autori principali: Eykelenboom, Jennifer E., Briggs, Gareth J., Bradshaw, Nicholas J., Soares, Dinesh C., Ogawa, Fumiaki, Christie, Sheila, Malavasi, Elise L.V., Makedonopoulou, Paraskevi, Mackie, Shaun, Malloy, Mary P., Wear, Martin A., Blackburn, Elizabeth A., Bramham, Janice, McIntosh, Andrew M., Blackwood, Douglas H., Muir, Walter J., Porteous, David J., Millar, J. Kirsty
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392113/
https://ncbi.nlm.nih.gov/pubmed/22547224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds169
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