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Ethanol Metabolism Activates Cell Cycle Checkpoint Kinase, Chk2
Chronic ethanol abuse results in hepatocyte injury and impairs hepatocyte replication. We have previously shown that ethanol metabolism results in cell cycle arrest at the G2/M transition, which is partially mediated by inhibitory phosphorylation of the cyclin-dependent kinase, Cdc2. To further deli...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3392032/ https://ncbi.nlm.nih.gov/pubmed/21924579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.alcohol.2011.07.005 |
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