Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation

There is a reciprocal interaction between pancreatic islet cells and vascular endothelial cells (EC) in which EC-derived signals promote islet cell differentiation and islet development while islet cell-derived angiogenic factors promote EC recruitment and extensive islet vascularization. To examine...

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Main Authors: Cai, Qing, Brissova, Marcela, Reinert, Rachel B., Pan, Fong Cheng, Brahmachary, Priyanka, Jeansson, Marie, Shostak, Alena, Radhika, Aramandla, Poffenberger, Greg, Quaggin, Susan E., Jerome, W. Gray, Dumont, Daniel J., Powers, Alvin C.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391601/
https://ncbi.nlm.nih.gov/pubmed/22546694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2012.04.022
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