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Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics
Animal studies demonstrated a role of neuropeptide nociceptin (NC) and its receptor (opiate receptor like-1, OPRL1) in ethanol-induced reward; activation of the OPRL1 by natural or synthetic ligands reduced ethanol self-administration and prevented relapse to ethanol drinking. The endogenous NC may...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3391552/ https://ncbi.nlm.nih.gov/pubmed/19501074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2009.05.067 |
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