Mapping of D4S98/S114/S113 confines the Huntington's defect to a reduced physical region at the telomere of chromosome 4.

The dominant gene defect in Huntington's disease (HD) is linked to the DNA marker D4S10, near the telomere of the chromosome 4 short arm. Two other markers, D4S43 and D4S95, are closer, but still proximal to the HD gene in 4p16.3. We have characterized a new locus, D4S114, identified by cloning...

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Detalhes bibliográficos
Main Authors: Whaley, W L, Michiels, F, MacDonald, M E, Romano, D, Zimmer, M, Smith, B, Leavitt, J, Bucan, M, Haines, J L, Gilliam, T C
Formato: Artigo
Idioma:Inglês
Publicado em: 1988
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC339109/
https://ncbi.nlm.nih.gov/pubmed/2905444
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