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Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance
The Gβγ heterodimer is an important signal transducer. Gβ, however, is prone to misfolding due to its requirement for Gγ and chaperones for proper folding. How cells dispose of misfolded Gβ (mfGβ) is not clear. Here, we showed that mfGβ was able to be polyubiquitinated and subsequently degraded by t...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3391016/ https://ncbi.nlm.nih.gov/pubmed/22430153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.41 |
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