Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer

Helicobacter hepaticus-infected Rag2(-/-) mice emulate many aspects of human inflammatory bowel disease, including the development of colitis and colon cancer. To elucidate mechanisms of inflammation-induced carcinogenesis, we undertook a comprehensive analysis of histopathology, molecular damage, a...

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Hauptverfasser: Mangerich, Aswin, Knutson, Charles G., Parry, Nicola M., Muthupalani, Sureshkumar, Ye, Wenjie, Prestwich, Erin, Cui, Liang, McFaline, Jose L., Mobley, Melissa, Ge, Zhongming, Taghizadeh, Koli, Wishnok, John S., Wogan, Gerald N., Fox, James G., Tannenbaum, Steven R., Dedon, Peter C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390855/
https://ncbi.nlm.nih.gov/pubmed/22689960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207829109
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