Conditional gene manipulation: Cre-ating a new biological era

To solve the problem of embryonic lethality in conventional gene knockouts, site-specific recombinase (SSR) systems (Cre-loxP, Flp-FRT, and ΦC31) have been used for tissue-specific gene knockout. With the combination of an SSR system and inducible gene expression systems (tetracycline and tamoxifen)...

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Bibliographic Details
Main Authors: Zhang, Jian, Zhao, Jing, Jiang, Wen-jie, Shan, Xi-wei, Yang, Xiao-mei, Gao, Jian-gang
Format: Artigo
Language:Inglês
Published: Zhejiang University Press 2012
Subjects:
Biotechnology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390709/
https://ncbi.nlm.nih.gov/pubmed/22761243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1631/jzus.B1200042
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