Structural and Functional Insight into How the Plasmodium falciparum VAR2CSA Protein Mediates Binding to Chondroitin Sulfate A in Placental Malaria

Malaria is a major global health problem. Pregnant women are susceptible to infection regardless of previously acquired immunity. Placental malaria is caused by parasites capable of sequestering in the placenta. This is mediated by VAR2CSA, a parasite antigen that interacts with chondroitin sulfate...

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Autors principals: Clausen, Thomas M., Christoffersen, Stig, Dahlbäck, Madeleine, Langkilde, Annette Eva, Jensen, Kamilla E., Resende, Mafalda, Agerbæk, Mette Ø., Andersen, Daniel, Berisha, Besim, Ditlev, Sisse B., Pinto, Vera V., Nielsen, Morten A., Theander, Thor G., Larsen, Sine, Salanti, Ali
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390611/
https://ncbi.nlm.nih.gov/pubmed/22570492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.348839
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