Pin1 Protein Regulates Smad Protein Signaling and Pulmonary Fibrosis

Interstitial pulmonary fibrosis is caused by the excess production of extracellular matrix (ECM) by Fb in response to TGF-β1. Here, we show that the peptidyl-prolyl isomerase Pin1 modulates the production of many pro- and antifibrogenic cytokines and ECM. After acute, bleomycin injury, Pin1(−/−) mic...

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Bibliographische Detailangaben
Hauptverfasser: Shen, Zhong-Jian, Braun, Ruedi K., Hu, Jie, Xie, Qifa, Chu, Haiyan, Love, Robert B., Stodola, Levi A., Rosenthal, Louis A., Szakaly, Renee J., Sorkness, Ronald L., Malter, James S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390608/
https://ncbi.nlm.nih.gov/pubmed/22613712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313684
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