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The Cholesterol-Dependent Cytolysin Signature Motif: A Critical Element in the Allosteric Pathway that Couples Membrane Binding to Pore Assembly

The cholesterol-dependent cytolysins (CDCs) constitute a family of pore-forming toxins that contribute to the pathogenesis of a large number of Gram-positive bacterial pathogens.The most highly conserved region in the primary structure of the CDCs is the signature undecapeptide sequence (ECTGLAWEWWR...

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Bibliografske podrobnosti
Main Authors: Dowd, Kelley J., Tweten, Rodney K.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390400/
https://ncbi.nlm.nih.gov/pubmed/22792065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002787
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