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Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF

Stress often has deleterious effects on cognition. We show that moderate stress enhanced late reversal learning in a mouse touchscreen-based choice task. Ventromedial prefrontal cortex (vmPFC) lesions mimicked the effects of stress, while orbitofrontal (OFC) and dorsolateral striatal (DLS) lesions i...

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Detalhes bibliográficos
Main Authors: Graybeal, Carolyn, Feyder, Michael, Schulman, Emily, Saksida, Lisa M., Bussey, Timothy J., Brigman, Jonathan L., Holmes, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389817/
https://ncbi.nlm.nih.gov/pubmed/22057192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2954
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