Chromosome instability and benefit from adjuvant anthracyclines in breast cancer

BACKGROUND: Duplication of the centromeric region of chromosome 17 (Ch17CEP) is associated with sensitivity to anthracyclines. An explanation may be chromosome instability (CIN); a frequent event in solid tumours associated with poor outcome. The predictive value of CIN seems to be drug dependent an...

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Bibliographic Details
Main Authors: Munro, A F, Twelves, C, Thomas, J S, Cameron, D A, Bartlett, J MS
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
Subjects:
Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389422/
https://ncbi.nlm.nih.gov/pubmed/22644297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.232
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