Targeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivo

BACKGROUND: The small stress heat shock protein 27 (Hsp27) has recently turned as a promising target for cancer treatment. Hsp27 upregulation is associated with tumour growth and resistance to chemo- and radio-therapeutic treatments, and several ongoing drugs inhibiting Hsp27 expression are under cl...

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Main Authors: Gibert, B, Eckel, B, Gonin, V, Goldschneider, D, Fombonne, J, Deux, B, Mehlen, P, Arrigo, A-P, Clézardin, P, Diaz-Latoud, C
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389402/
https://ncbi.nlm.nih.gov/pubmed/22627320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.188
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