Suppression of tumour-specific CD4(+) T cells by regulatory T cells is associated with progression of human colorectal cancer

BACKGROUND: There is indirect evidence that T cell responses can control the metastatic spread of colorectal cancer (CRC). However, an enrichment of CD4(+)Foxp3(+) regulatory T cells (Tregs) has also been documented. OBJECTIVE: To evaluate whether CRC promotes Treg activity and how this influences a...

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Detalhes bibliográficos
Main Authors: Betts, Gareth, Jones, Emma, Junaid, Syed, El-Shanawany, Tariq, Scurr, Martin, Mizen, Paul, Kumar, Mayur, Jones, Sion, Rees, Brian, Williams, Geraint, Gallimore, Awen, Godkin, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2011
Assuntos:
Colon
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388728/
https://ncbi.nlm.nih.gov/pubmed/22207629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-300970
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