Characterization of Autoantibodies against the E1α Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis

Primary biliary cirrhosis (PBC) is characterized by antimitochondrial antibodies (AMAs) that react with the lipoyl-containing E2 subunits of 2-oxoacid dehydrogenase complexes such as BCOADC and PDC. The lipoyl domains of E2 contain the major epitopes essential for immunopathology. However, the non-l...

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Detalhes bibliográficos
Main Authors: Mori, Tsutomu, Ohira, Hiromasa, Kuroda, Masahito, Kato, Masaki, Yamaguchi, Yoshiki, Kochi, Hideo
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388300/
https://ncbi.nlm.nih.gov/pubmed/22778969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/369740
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