Tissue inhibitor of metalloproteinases-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: mechanisms and relevance to HIV-1-associated dementia

HIV-1-associated dementia (HAD)-relevant proinflammatory cytokines robustly induce astrocyte tissue inhibitor of metalloproteinases-1 (TIMP-1). As TIMP-1 displays pleotropic functions, we hypothesized that TIMP-1 expression may serve as a neuroprotective response of astrocytes. Previously, we report...

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Detalhes bibliográficos
Main Authors: Ashutosh, Chao, C, Borgmann, K, Brew, K, Ghorpade, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388228/
https://ncbi.nlm.nih.gov/pubmed/22739984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.54
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