Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment: Chemoprevention with Rapamycin, an mTOR Inhibitor and Anti-Aging Drug

Increasing chronological age is the most significant risk factor for human cancer development. To examine the effects of host aging on mammary tumor growth, we used caveolin (Cav)-1 knockout mice as a bona fide model of accelerated host aging. Mammary tumor cells were orthotopically implanted into t...

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Detalhes bibliográficos
Main Authors: Mercier, Isabelle, Camacho, Jeanette, Titchen, Kanani, Gonzales, Donna M., Quann, Kevin, Bryant, Kelly G., Molchansky, Alexander, Milliman, Janet N., Whitaker-Menezes, Diana, Sotgia, Federica, Jasmin, Jean-François, Schwarting, Roland, Pestell, Richard G., Blagosklonny, Mikhail V., Lisanti, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2012
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388151/
https://ncbi.nlm.nih.gov/pubmed/22698676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.03.017
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