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Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase

The vast majority of small molecules known to modulate kinase activity, target the highly conserved ATP-pocket. Consequently, such ligands are often less specific and in case of inhibitors, this leads to the inhibition of multiple kinases. Thus, selective modulation of kinase function remains a majo...

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Detalhes bibliográficos
Main Authors: Getlik, Matthäus, Simard, Jeffrey R., Termathe, Martin, Grütter, Christian, Rabiller, Matthias, van Otterlo, Willem A. L., Rauh, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388095/
https://ncbi.nlm.nih.gov/pubmed/22768308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039713
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