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Fidaxomicin Is an Inhibitor of the Initiation of Bacterial RNA Synthesis

Fidaxomicin was recently approved for the treatment of Clostridium difficile infection. It inhibits transcription by bacterial RNA polymerase. Because transcription is a multistep process, experiments were conducted in which fidaxomicin was added at different stages of transcriptional initiation to...

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Bibliografische gegevens
Hoofdauteurs: Artsimovitch, Irina, Seddon, Jaime, Sears, Pamela
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388026/
https://ncbi.nlm.nih.gov/pubmed/22752861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/cis358
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