R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts

R848, also known as resiquimod, acts as a ligand for toll-like receptor 7 (TLR7) and activates immune cells. In this study, we examined the effects of R848 on differentiation, survival, and bone-resorbing function of osteoclasts. R848 inhibited osteoclast differentiation of mouse bone marrow-derived...

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Bibliographic Details
Main Authors: Miyamoto, Arei, Takami, Masamichi, Matsumoto, Akifumi, Mochizuki, Ayako, Yamada, Takako, Tachi, Keita, Shibuya, Isao, Nakamachi, Tomoya, Shioda, Seiji, Baba, Kazuyoshi, Inoue, Tomio, Miyamoto, Yoichi, Yim, Mijung, Kamijo, Ryutaro
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2012
Subjects:
JAACT Special Issue
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386391/
https://ncbi.nlm.nih.gov/pubmed/22358541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-012-9442-5
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