Enzymatic Degradation of PrP(Sc) by a Protease Secreted from Aeropyrum pernix K1

BACKGROUND: An R30 fraction from the growth medium of Aeropyrum pernix was analyzed for the protease that can digest the pathological prion protein isoform (PrP(Sc)) from different species (human, bovine, deer and mouse). METHODOLOGY/PRINCIPAL FINDINGS: Degradation of the PrP(Sc) isoform by the R30...

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Autori principali: Šnajder, Marko, Vilfan, Tanja, Černilec, Maja, Rupreht, Ruth, Popović, Mara, Juntes, Polona, Šerbec, Vladka Čurin, Ulrih, Nataša Poklar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386259/
https://ncbi.nlm.nih.gov/pubmed/22761822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039548
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