Enzymatic Degradation of PrP(Sc) by a Protease Secreted from Aeropyrum pernix K1

BACKGROUND: An R30 fraction from the growth medium of Aeropyrum pernix was analyzed for the protease that can digest the pathological prion protein isoform (PrP(Sc)) from different species (human, bovine, deer and mouse). METHODOLOGY/PRINCIPAL FINDINGS: Degradation of the PrP(Sc) isoform by the R30...

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Detalhes bibliográficos
Main Authors: Šnajder, Marko, Vilfan, Tanja, Černilec, Maja, Rupreht, Ruth, Popović, Mara, Juntes, Polona, Šerbec, Vladka Čurin, Ulrih, Nataša Poklar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386259/
https://ncbi.nlm.nih.gov/pubmed/22761822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039548
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