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Nucleotide-dependent conformations of FtsZ dimers and force generation observed through molecular dynamics simulations

The bacterial cytoskeletal protein FtsZ is a GTPase that is thought to provide mechanical constriction force via an unidentified mechanism. Purified FtsZ polymerizes into filaments with varying structures in vitro: while GTP-bound FtsZ assembles into straight or gently curved filaments, GDP-bound Ft...

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Main Authors: Hsin, Jen, Gopinathan, Ajay, Huang, Kerwyn C.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386107/
https://ncbi.nlm.nih.gov/pubmed/22647609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120761109
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