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Functional modulation of a protein folding landscape via side-chain distortion
Ultrahigh-resolution (< 1.0 Å) structures have revealed unprecedented and unexpected details of molecular geometry, such as the deformation of aromatic rings from planarity. However, the functional utility of such energetically costly strain is unknown. The 0.83 Å structure of α-lytic protease (α...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3386061/ https://ncbi.nlm.nih.gov/pubmed/22635267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119274109 |
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