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Diagnosis of alpha 1-antitrypsin deficiency by enzymatic amplification of human genomic DNA and direct sequencing of polymerase chain reaction products.

We have compared sequencing of cloned "polymerase chain reaction" (PCR) products and the direct sequencing of PCR products in the examination of individuals from six families affected with alpha 1-antitrypsin (AAT) deficiency. In families where paternity was in question we confirmed consan...

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Autors principals: Newton, C R, Kalsheker, N, Graham, A, Powell, S, Gammack, A, Riley, J, Markham, A F
Format: Artigo
Idioma:Inglês
Publicat: 1988
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC338555/
https://ncbi.nlm.nih.gov/pubmed/3262215
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