Air2p is critical for the assembly and RNA-binding of the TRAMP complex and the KOW domain of Mtr4p is crucial for exosome activation

Trf4/5p-Air1/2p-Mtr4p polyadenylation complex (TRAMP) is an essential component of nuclear RNA surveillance in yeast. It recognizes a variety of nuclear transcripts produced by all three RNA polymerases, adds short poly(A) tails to aberrant or unstable RNAs and activates the exosome for their degrad...

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Detalhes bibliográficos
Main Authors: Holub, Peter, Lalakova, Jana, Cerna, Hana, Pasulka, Josef, Sarazova, Marie, Hrazdilova, Kristyna, Arce, Maria Sanudo, Hobor, Fruzsina, Stefl, Richard, Vanacova, Stepanka
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384339/
https://ncbi.nlm.nih.gov/pubmed/22402490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks223
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