HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells

Hypoxia-inducible factors (HIF)-1α and HIF2α are major transcription factors required for adaptive responses to hypoxia. HIFs form a complex with aryl hydrocarbon receptor nuclear translocator (ARNT) to bind to the regulatory regions of target genes. The acetylation of histones by histone acetyltran...

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Hlavní autoři: Koizume, Shiro, Ito, Shin, Miyagi, Etsuko, Hirahara, Fumiki, Nakamura, Yoshiyasu, Sakuma, Yuji, Osaka, Hitoshi, Takano, Yasuo, Ruf, Wolfram, Miyagi, Yohei
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Gene Regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384323/
https://ncbi.nlm.nih.gov/pubmed/22402494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks201
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