Structural and functional characterization of interactions involving the Tfb1 subunit of TFIIH and the NER factor Rad2

The general transcription factor IIH (TFIIH) plays crucial roles in transcription as part of the pre-initiation complex (PIC) and in DNA repair as part of the nucleotide excision repair (NER) machinery. During NER, TFIIH recruits the 3′-endonuclease Rad2 to damaged DNA. In this manuscript, we functi...

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Bibliographic Details
Main Authors: Lafrance-Vanasse, Julien, Arseneault, Geneviève, Cappadocia, Laurent, Chen, Hung-Ta, Legault, Pascale, Omichinski, James G.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384317/
https://ncbi.nlm.nih.gov/pubmed/22373916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks194
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