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Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1
Translation termination in eukaryotes is catalyzed by two release factors eRF1 and eRF3 in a cooperative manner. The precise mechanism of stop codon discrimination by eRF1 remains obscure, hindering drug development targeting aberrations at translation termination. By solving the solution structures...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3384315/ https://ncbi.nlm.nih.gov/pubmed/22383581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks192 |
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