Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies

Although formation of urothelial carcinoma of the bladder (UCB) requires multiple steps and proceeds along divergent pathways, the underlying genetic and molecular determinants for each step and pathway remain undefined. By developing transgenic mice expressing single or combinatorial genetic altera...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Haiping, Huang, Hong-ying, Shapiro, Ellen, Lepor, Herbert, Huang, William C., Mohammadi, Moosa, Mohr, Ian, Tang, Moon-shong, Huang, Chuanshu, Wu, Xue-Ru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Biology, Genetics and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384072/
https://ncbi.nlm.nih.gov/pubmed/22287562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs025
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