Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies

Although formation of urothelial carcinoma of the bladder (UCB) requires multiple steps and proceeds along divergent pathways, the underlying genetic and molecular determinants for each step and pathway remain undefined. By developing transgenic mice expressing single or combinatorial genetic altera...

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Detalhes bibliográficos
Main Authors: Zhou, Haiping, Huang, Hong-ying, Shapiro, Ellen, Lepor, Herbert, Huang, William C., Mohammadi, Moosa, Mohr, Ian, Tang, Moon-shong, Huang, Chuanshu, Wu, Xue-Ru
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Biology, Genetics and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384072/
https://ncbi.nlm.nih.gov/pubmed/22287562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs025
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