Structural Basis for Polyadenosine-RNA Binding by Nab2 Zn Fingers and Its Function in mRNA Nuclear Export

Polyadenylation regulation and efficient nuclear export of mature mRNPs both require the polyadenosine-RNA-binding protein, Nab2, which contains seven CCCH Zn fingers. We describe here the solution structure of fingers 5-7, which are necessary and sufficient for high-affinity polyadenosine-RNA bindi...

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Detalhes bibliográficos
Main Authors: Brockmann, Christoph, Soucek, Sharon, Kuhlmann, Sonja I., Mills-Lujan, Katherine, Kelly, Seth M., Yang, Ji-Chun, Iglesias, Nahid, Stutz, Francoise, Corbett, Anita H., Neuhaus, David, Stewart, Murray
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384006/
https://ncbi.nlm.nih.gov/pubmed/22560733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.03.011
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