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Artificial mirtron-mediated gene knockdown: Functional DMPK silencing in mammalian cells
Mirtrons are introns that form pre-miRNA hairpins after splicing to produce RNA interference (RNAi) effectors distinct from Drosha-dependent intronic miRNAs. Here we present a design algorithm for artificial mirtrons and demonstrate, for the first time, efficient gene knockdown of myotonic dystrophy...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383964/ https://ncbi.nlm.nih.gov/pubmed/22647847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.030601.111 |
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