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Somatic mitochondrial DNA mutations in early Parkinson's and incidental Lewy body disease

Somatic mutations in mitochondrial DNA (mtDNA) are hypothesized to play a role in Parkinson disease (PD), but large increases in mtDNA mutations have not previously been found in PD, potentially because neurons with high mutation levels degenerate and thus are absent in late-stage tissue. To address...

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Main Authors: Lin, Michael T., Cantuti-Castelvetri, Ippolita, Zheng, Kangni, Jackson, Katie E., Tan, Yong B., Arzberger, Thomas, Lees, Andrew J., Betensky, Rebecca A., Beal, M. Flint, Simon, David K.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383820/
https://ncbi.nlm.nih.gov/pubmed/22718549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23568
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