Somatic mitochondrial DNA mutations in early Parkinson's and incidental Lewy body disease

Somatic mutations in mitochondrial DNA (mtDNA) are hypothesized to play a role in Parkinson disease (PD), but large increases in mtDNA mutations have not previously been found in PD, potentially because neurons with high mutation levels degenerate and thus are absent in late-stage tissue. To address...

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Detalhes bibliográficos
Main Authors: Lin, Michael T., Cantuti-Castelvetri, Ippolita, Zheng, Kangni, Jackson, Katie E., Tan, Yong B., Arzberger, Thomas, Lees, Andrew J., Betensky, Rebecca A., Beal, M. Flint, Simon, David K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383820/
https://ncbi.nlm.nih.gov/pubmed/22718549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23568
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