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N-Myc and GCN5 Regulate Significantly Overlapping Transcriptional Programs in Neural Stem Cells
Here we examine the functions of the Myc cofactor and histone acetyltransferase, GCN5/KAT2A, in neural stem and precursor cells (NSC) using a conditional knockout approach driven by nestin-cre. Mice with GCN5-deficient NSC exhibit a 25% reduction in brain mass with a microcephaly phenotype similar t...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383708/ https://ncbi.nlm.nih.gov/pubmed/22745758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039456 |
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