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N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor

Myc proteins have long been modeled to operate strictly as classical gene specific transcription factors, however we find that N-Myc has a robust role in the human genome in regulating global cellular euchromatin including that of intergenic regions. Strikingly, 90–95% of the total genomic euchromat...

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Detalhes bibliográficos
Principais autores: Cotterman, Rebecca, Jin, Victor X., Krig, Sheryl R., Lemen, Jessica M., Wey, Alice, Farnham, Peggy J., Knoepfler, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637654/
https://ncbi.nlm.nih.gov/pubmed/19047142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1961
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