N-Myc and GCN5 Regulate Significantly Overlapping Transcriptional Programs in Neural Stem Cells

Here we examine the functions of the Myc cofactor and histone acetyltransferase, GCN5/KAT2A, in neural stem and precursor cells (NSC) using a conditional knockout approach driven by nestin-cre. Mice with GCN5-deficient NSC exhibit a 25% reduction in brain mass with a microcephaly phenotype similar t...

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Main Authors: Martínez-Cerdeño, Verónica, Lemen, Jessica M., Chan, Vanessa, Wey, Alice, Lin, Wenchu, Dent, Sharon R., Knoepfler, Paul S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383708/
https://ncbi.nlm.nih.gov/pubmed/22745758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039456
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