A Phase I clinical and pharmacology study using amifostine as a radioprotector in dose-escalated whole liver radiation therapy

PURPOSE: Diffuse intrahepatic tumors are difficult to control. Whole liver radiotherapy has been limited by toxicity, most notably radiation-induced liver disease (RILD). Amifostine is a prodrug free-radical scavenger that selectively protects normal tissues and, in a preclinical model of intrahepat...

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Detalhes bibliográficos
Main Authors: Feng, Mary, Smith, David E., Normolle, Daniel P., Knol, James A., Pan, Charlie C., Ben-Josef, Edgar, Lu, Zheng, Feng, Meihua R., Chen, Jun, Ensminger, William, Lawrence, Theodore S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383372/
https://ncbi.nlm.nih.gov/pubmed/22440042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2011.10.020
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