Infectivity in chimpanzees (Pan troglodytes) of plasma collected before HCV RNA detectability by FDA-licensed assays: implications for transfusion safety and HCV infection outcomes

Serial plasma aliquots (50 mL) obtained from 10 commercial donors who converted from hepatitis C virus (HCV) RNA negative to positive were transfused into 2 chimpanzees to assess infectivity during early HCV infection. Plasma, obtained 4 days before HCV RNA detectability by licensed assays, transmit...

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Detalhes bibliográficos
Main Authors: Busch, Michael P., Murthy, Krishna K., Kleinman, Steven H., Hirschkorn, Dale F., Herring, Belinda L., Delwart, Eric L., Racanelli, Vito, Yoon, Joo Chun, Rehermann, Barbara, Alter, Harvey J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Transfusion Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383200/
https://ncbi.nlm.nih.gov/pubmed/22498743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-393637
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