Impact of immune modulation with in vivo T-cell depletion and myleoablative total body irradiation conditioning on outcomes after unrelated donor transplantation for childhood acute lymphoblastic leukemia

To determine whether in vivo T-cell depletion, which lowers GVHD, abrogates the antileukemic benefits of myeloablative total body irradiation–based conditioning and unrelated donor transplantation, in the present study, we analyzed 715 children with acute lymphoblastic leukemia. Patients were groupe...

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Main Authors: Veys, Paul, Wynn, Robert F., Ahn, Kwang Woo, Samarasinghe, Sujith, He, Wensheng, Bonney, Denise, Craddock, John, Cornish, Jacqueline, Davies, Stella M., Dvorak, Christopher C., Duerst, Reggie E., Gross, Thomas G., Kapoor, Neena, Kitko, Carrie, Krance, Robert A., Leung, Wing, Lewis, Victor A., Steward, Colin, Wagner, John E., Carpenter, Paul A., Eapen, Mary
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2012
Teme:
Clinical Trials and Observations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383023/
https://ncbi.nlm.nih.gov/pubmed/22573402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-405795
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