Prophylactic rituximab after allogeneic transplantation decreases B-cell alloimmunity with low chronic GVHD incidence

B cells are involved in the pathogenesis of chronic GVHD (cGVHD). We hypothesized that prophylactic anti–B-cell therapy delivered 2 months after transplantation would decrease allogeneic donor B-cell immunity and possibly the incidence of cGVHD. Therefore, in the present study, patients with high-ri...

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Detalhes bibliográficos
Main Authors: Arai, Sally, Sahaf, Bita, Narasimhan, Balasubramanian, Chen, George L., Jones, Carol D., Lowsky, Robert, Shizuru, Judith A., Johnston, Laura J., Laport, Ginna G., Weng, Wen-Kai, Benjamin, Jonathan E., Schaenman, Joanna, Brown, Janice, Ramirez, Jessica, Zehnder, James L., Negrin, Robert S., Miklos, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383022/
https://ncbi.nlm.nih.gov/pubmed/22563089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-395970
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