Nucleotide-dependent conformational changes in the N-Ethylmaleimide Sensitive Factor (NSF) and their potential role in SNARE complex disassembly

Homohexameric, N-Ethylmaleimide Sensitive Factor (NSF) disassembles Soluble NSF Attachment Protein Receptor (SNARE) complexes after membrane fusion, an essential step in vesicular trafficking. NSF contains three domains (NSF-N, NSF-D1, and NSF-D2), each contributing to activity. We combined electron...

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Autores principales: Moeller, Arne, Zhao, Chunxia, Fried, Michael G., Wilson-Kubalek, Elizabeth M., Carragher, Bridget, Whiteheart, Sidney W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382979/
https://ncbi.nlm.nih.gov/pubmed/22245547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2011.12.018
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