Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer

CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) have emerged as a dominant T cell population inhibiting anti-tumor effector T cells. Initial strategies used for Treg-depletion (cyclophosphamide, anti-CD25 mAb…) also targeted activated T cells, as they share many phenotypic markers. Current, ameliora...

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Main Authors: Pere, Helene, Tanchot, Corinne, Bayry, Jagadeesh, Terme, Magali, Taieb, Julien, Badoual, Cecile, Adotevi, Olivier, Merillon, Nathalie, Marcheteau, Elie, Quillien, Ve´ronique, Banissi, Claire, Carpentier, Alain, Sandoval, Federico, Nizard, Mevyn, Quintin-Colonna, Françoise, Kroemer, Guido, Fridman, Wolf H., Zitvogel, Laurence, Oudard, Ste´phane, Tartour, Eric
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382865/
https://ncbi.nlm.nih.gov/pubmed/22737608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.18852
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