Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype

We generated transgenic mice that express a constitutively active mutant of MEK1 in chondrocytes. These mice showed a dwarf phenotype similar to achondroplasia, the most common human dwarfism, caused by activating mutations in FGFR3. These mice displayed incomplete hypertrophy of chondrocytes in the...

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Pubblicato in:	Genes Dev
Autori principali:	Murakami, Shunichi, Balmes, Gener, McKinney, Sandra, Zhang, Zhaoping, Givol, David, de Crombrugghe, Benoit
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2004
Soggetti:	Research Papers
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC338282/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14871928/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1179104
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