Immunotoxin-Mediated Tract Targeting in the Primate Brain: Selective Elimination of the Cortico-Subthalamic “Hyperdirect” Pathway

Using a neuron-specific retrograde gene-transfer vector (NeuRet vector), we established immunotoxin (IT)-mediated tract targeting in the primate brain that allows ablation of a neuronal population constituting a particular pathway. Here, we attempted selective removal of the cortico-subthalamic “hyp...

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Bibliographic Details
Main Authors: Inoue, Ken-ichi, Koketsu, Daisuke, Kato, Shigeki, Kobayashi, Kazuto, Nambu, Atsushi, Takada, Masahiko
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382612/
https://ncbi.nlm.nih.gov/pubmed/22761729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039149
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